Does it slow aging process?

If you're willing to pay thousands, some doctors promise to reverse the signs of aging with human growth hormone (HGH). Before you sign up, get the facts.

Your body naturally makes growth hormone to help fuel growth during your childhood and to help maintain your tissues and organs throughout your life. Beginning in your 40s, your pituitary gland — the pea-sized structure at the base of your brain where growth hormone is made — slowly reduces the amount of the hormone it produces.

Some people believe the dwindling level of growth hormone is responsible for the frailty that typically comes with getting older. And that's prompted some who are concerned about growing old and losing independence to turn to injections of synthetic human growth hormone (HGH) to stave off the realities of old age. Studies of adults with growth hormone deficiencies show that injections of human growth hormone can:

    * Increase bone density

    * Increase muscle mass

    * Decrease body fat

    * Bolster the heart's ability to contract

    * Improve mood and motivation

    * Increase exercise capacity

Hormones

DHEA (dehydroepiandrosterone) is an adrenal hormone that is the precursor for steroid hormones such as testosterone and estrogen. DHEA declines precipitously with advancing age in both men and women. In 1981, the Life Extension Foundation introduced DHEA (dehydroepiandrosterone) to its members through an article that described the multiple benefits that this hormone might produce. However, the general public did not learn about DHEA supplements until 1996, when the benefits of DHEA were touted by the news media and in several popular books. DHEA became credible to the medical establishment when the New York Academy of Sciences published a book entitled DHEA and Aging. This book provided scientific validation for the many life extending effects of DHEA.

The hormonal stimulus for sex drive in both men and women is testosterone, which declines with advancing age in both sexes. Testosterone also plays an important role in maintaining muscle mass and strength and bone density. The hormone is often administered to aging men and women as a topical cream, but oral testosterone supplements and injectable forms are also available.

The "female" steroid hormones estrogen and progesterone play important roles in maintaining bone density and strength, sexual function, mental function and, in women, in countering the effects of the menopause. Recent studies indicate that estrogen may be an effective treatment for age-associated memory problems.* Both estrogen and progesterone are available in a variety of forms -- natural or synthetic, oral or topical. There is considerable interest in the use of plant-derived phytoestrogens, which have weak (but safe) estrogenic activity as a possible replacement for drug forms of estrogen. One product, Natural Estrogen, has been specially designed for this purpose.

Melatonin is a hormone produced by the pineal gland, which is located beneath the brain. Melatonin is a highly potent antioxidant, which has been described as the pacemaker of the aging clock in humans. It is released every night as part of our time-dependent biorhythms to help induce sleep and recuperation from fatigue. Published studies indicate the importance of maintaining youthful levels of melatonin to help protect against age-related degenerative diseases.

Pregnenolone is known as the "mother hormone" because it is the precursor of a number of hormones including DHEA, testosterone and estrogen. Studies have demonstrated that the neurosteroid Pregnenolone has a stimulatory effect on memory.

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