Semaglutide is an injectable prescription medication originally approved for treating type 2 diabetes. More recently, a higher dose formulation called Wegovy was approved specifically for chronic weight management.
Semaglutide works by mimicking the hormone GLP-1, which helps regulate blood sugar and appetite. It helps lower blood sugar levels and promotes feelings of fullness so you eat less.
Several clinical trials have shown that semaglutide is effective for weight loss when used with lifestyle interventions like diet and exercise. In one study, people taking semaglutide lost an average of 15% of their body weight over 68 weeks.
Getting a prescription
- Speak to your doctor about whether semaglutide is appropriate for you. Not everyone is a candidate.
- Semaglutide is usually only prescribed if you have obesity (BMI ≥30) or overweight (BMI 27-29.9) with at least one weight-related health condition like diabetes, high blood pressure or high cholesterol.
- Your doctor will check if you meet all eligibility criteria through medical history, exam and lab tests before prescribing.
What to expect if prescribed
- Dosage - The starting dosage is 0.25 mg injected under the skin once weekly. This is increased gradually up to 2.4 mg per week.
- Side effects - The most common side effects are nausea, diarrhea, vomiting, constipation and stomach pain. These are usually mild and improve over time.
- Cost - Semaglutide is expensive. Most insurance plans cover some portion with prior authorization. Manufacturer coupons and patient assistance programs are also available to lower out-of-pocket costs.
- Duration - Weight loss is progressive over 30 weeks. Maintenance treatment may continue if beneficial. Your doctor will monitor progress and effects regularly.
Alternatives
Below are some alternatives if semaglutide is not accessible or appropriate:
- Prescription medications - Other GLP-1 drugs like liraglutide or short-term phentermine may be options. Your doctor can help determine if you qualify.
- OTC supplements - Some over-the-counter diet pills may have modest effects but likely not as substantial as prescription drugs. Research thoroughly and consult your physician before using any supplement.
- Lifestyle interventions - Evidence-based programs for nutrition, physical activity, behavior change and support can promote clinically meaningful weight loss and improved health. This remains essential even with medications.
If struggling with excess weight, have an open discussion with your doctor. Together you can explore treatment options that give you the best chance of long-term success.